I had a fantastic experience. The first thing that stood out was the exceptional cleanliness—the rooms were spotless, well-maintained, and fresh every day. The housekeeping team did an outstanding job, ensuring everything was perfectly arranged and sanitized. Beyond cleanliness, the hotel had a modern and stylish design, creating a cozy yet elegant atmosphere. The location was also a big plus, conveniently close to major attractions and public transport, making it easy to explore Rome. The staff were friendly and professional, always ready to assist with any requests. Overall, I highly recommend Twenty One Hotel for anyone visiting Rome, especially if cleanliness and comfort are top priorities!

The hotel is quite busy, and with many guests coming and going, having only one entrance can feel a bit congested. Adding another entrance or improving the flow at the main one could make check-in and access smoother, especially during peak hours.

the hotel location, close to the centrum , walking distance; the staff is customer oriented but more carefully to read the visitors preferences

the staff in 4 star hotel is expected to read well the visitors preferences and to try to meet them since the arrival. The rooms we asked for are NOT to face a noisy road . The 1st night we had to listen to the night traffic , not able to sleep. Then , the staff arranged to move us to the rooms , facing kind of inner yard - thanks for this reaction. However the rooms were so hot , no cooling yet of the hotel air-conditioning and the air from the inner yard was also hot and for sure nor fresh ...

Location is great, actually I booked this hotel because I knew its location from before (I knew the hotel only from outside). The stuff was very friendly, either at reception desk, or during the breakfast. I was pleasantly surprised because I was offered with the "breakfast box", since I had to leave the hotel early in the morning.

For 4* hotel the room furniture is a little bit "tired" and the rooms should be renovated; that is why I have written that the hotel didn't meet my expectations. Besides that, blankets were old-fashioned, although I have to admit, the rooms were very clean and well maintained in terms of everyday service. Breakfast was not bad, but could be a little bit better with the choice.

Our stay at the Twenty One Hotel was one of the most memorable highlights of our trip to Italy. Ideally located, the hotel provides easy access to many attractions. The rooms were beautifully decorated, with efficient space management and artistic touches evident in every corner. The attention to detail made the entire experience feel luxurious and special. The rooftop restaurant and bar is a must-visit. From this vantage point, you can enjoy a delightful meal or drink while catching a glimpse of the Vatican in the distance. It's an experience that adds an unforgettable charm to your stay.

nothing as such!

The location was brilliant for exploring historical Rome on foot or by public transport. The breakfast was lovely, the evening dinner was fantastic , and the views from the rooftop restaurant are brilliant. The bathroom was nice, with a powerful warm shower. The concierge staff are really helpful and it was easy for them to order a taxi when needed.

The round bed was a bit small for a 6ft+ person as my feet were off the end of the edges of the bed, which wasn't great for my back, but I still slept well as so tired from exploring during the day. The jacuzzi bath in the room didn't work so couldn't use the jacuzzi features but still could use purely as a bath. The ceiling had suffered from some damp from excess moisture in the room from the bath/shower, we opened the windows to let the moisture out after showering but clearly other guests hadn't which has led to the ceiling damage. There also wasn't any English speaking TV channels that work, not a huge issue as we just listened to BBC sounds radio on our phones instead or watched Netflix on our tablet, however you'd expect maybe at least one (classic BBC world news or something).

The breakfast was excellent, offering a variety of dishes such as scrambled eggs, rice, and more. Enjoying breakfast with a stunning view of the Vatican was a highlight. The hotel's location is perfect, with all major attractions within walking distance.

What we didn’t like was that the room had an odd shape in the corner, making the wardrobe quite small. The bathroom door didn’t provide much privacy, serving more as decoration than a proper door. The walls were relatively thin, so we could hear noises from other rooms.

The hotel is well connected to all the main attractions in Rome. It is also located on a very nice street which is close enough to Pharmacies, stores & good restaurants. It was very clean and the staff were very friendly and helpful throughout our stay. The breakfast buffet is also a must not to be missed! My family and I requested & booked conjoined rooms which was very ideal for when we needed to chat in the mornings. I would definitely recommend this place 100% would certainly choose to stay there again in the future.

We had a wonderful stay at the TwentyOne Hotel in Rome. The room was cozy but very clean and maintained daily, which made our stay comfortable. The hotel's location in the Prati district is excellent, being close to the Vatican and just a 45-minute walk to the Colosseum. We spent the whole week by traveling on foot (over 100km) and the hotel was a great starting point for all of our ventures. Hotel staff were friendly and responsive, ensuring all our needs were met. On the day of our departure, we were offered a courtesy room with shower and amenities, allowing us to refresh and change before our flight. Overall, we highly recommend the TwentyOne Hotel for its cleanliness, prime location, and excellent service.

A nitpick really, but breakfasts could be a bit more varied during the week.

A modern 4 stars hotel close to Lepanto metro station. At the outskirts of Rome historic centre which one could reach on foot - around 1,5km walking. Very close to Piaza del Popolo. Clean and rather ample room with all modern amenities. Breakfast superior. Dinner very good bad expensive - around 80 euros the couple with a glass of wine at 8 euros. Overall it is a rather expensive hotel (180 euros per night in early March) for some good reasons. Good value for money? Not sure.

Delidious breakfast and convenient location.