The hotel offers four types of rooms: Suite, Superior Double Room, Standard Double Room, and Junior Suite. The Suite and Junior Suite are both suites and are larger in size, with the Suite being the largest at 431 sqft. The Superior Double Room and Standard Double Room are both double rooms and are smaller in size, with the Standard Double Room being the smallest at 161 sqft. Smoking is not allowed in any of the rooms. The rooms accommodate varying numbers of adults and children, with the Suite and Junior Suite accommodating more than two adults. All the rooms have Queen size beds, except for the Junior Suite which also has a Twin bed.

The Relais Santa Maria Maggiore offers various leisure amenities for guests to enjoy during their stay. They provide a fully-equipped fitness center, ideal for those who wish to maintain their fitness routine. Guests can also relax and unwind in the hotel's sauna after a long day of exploring the city.

The hotel also offers the convenience of onsite dining options, with a bar and restaurant available for guests to enjoy a delicious meal or a refreshing drink.

Additionally, the hotel provides a 24-hour front desk service, ensuring that guests have all the assistance they need throughout their stay. This includes tour assistance, car rental, and concierge services.

With its central location, guests can easily access the historical sites and attractions in Rome, making it an ideal base for sightseeing.